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Press releases 2004

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Press releases are intended to journalists, analysts and investors.

Approval of the merger of Aventis with and into Sanofi-aventis

December 23, 2004

Sanofi-aventis to reorganise short-term financing

December 22, 2004

Sanofi-aventis receives Patent Office’s Notice of Allowance on its reissuance application for Lovenox ‘618 patent.

December 20, 2004

Taxotere® (docetaxel) regimen significantly improves survival in women with node positive early stage breast cancer

December 10, 2004

Update of patent litigation schedules in the United States for Plavix® and Lovenox®

December 9, 2004

First International Registry of Patients with Early Stage Breast Cancer Launched

December 7, 2004

Eloxatin™ (oxaliplatin for injection) based therapy combined with bevacizumab (Avastin™) significantly improves survival in patients with advanced colorectal cancer

November 29, 2004

Proposed Relocation of Aventis’ headquarters from Strasbourg to Paris

November 25, 2004

Aventis, part of the sanofi-aventis Group, announced termination of its agreements with Genta

November 9, 2004

Eloxatin™ (oxaliplatin for injection) receives FDA approval for the treatment of colon cancer following surgery (adjuvant treatment)

November 5, 2004

Possibility of increase in price of mandatory offer of sanofi-aventis to shareholders of Hoechst AG to EUR 56.50 per Hoechst share

November 4, 2004

European Union Approval for Taxotere® (docetaxel) in Prostate Cancer

November 4, 2004

Aventis Receives Approvable Letter from U.S. Food and Drug Administration for Alvesco® (ciclesonide) for Treatment of Persistent Asthma

October 26, 2004

Sales momentum maintained, rapid progress on integration - Sustained growth in proforma combined net sales: 10.5% for the first nine months of 2004

October 21, 2004

Proposed Merger of Aventis into sanofi-aventis

October 14, 2004

Strengthening of the Alliance on Actonel® between the Sanofi-aventis Group and Procter & Gamble

October 8, 2004

sanofi-aventis launches its mandatory offer to the shareholders of Hoechst Aktiengesellschaft. Offer document cleared by German Financial Supervisory Authority (BaFin)

October 1, 2004

New appointments in the sanofi-aventis Group

September 22, 2004

Appointments at the Communications Department of the sanofi-aventis Group

September 22, 2004

Eloxatin® to receive expanded indication in Europe for early stage colorectal cancer treatment

September 17, 2004

The sanofi-aventis Group thanks its team members and shareholders and launches its new visual identity

September 16, 2004

Final results of sanofi-aventis’ offer for Aventis: After subsequent offering period, sanofi-aventis holds 98.03% of Aventis share capital

September 16, 2004

sanofi-aventis’ offer for Aventis subsequent offering period has expired

September 7, 2004

Appointments of a hundred managers in 70 countries in the sanofi-aventis group

September 6, 2004

Agnès Garcia-Gibot is appointed Director of International Internal Communications and Corporate Image for Sanofi-Aventis

September 1, 2004

Excellent first half of 2004 for Sanofi-Synthelabo. Strong growth in EPS* in the first half of 2004: 21.6% on a reported basis; 32.8% at 2003 exchange rates

August 31, 2004

Olivier Jacquesson becomes head of Business Development

August 30, 2004

Mandatory Publication pursuant to Sections 35 sub-sec. 1, 10 sub-sec. 3 Securities Acquisition and Takeover Act (WpÜG) – Mandatory Offer

August 23, 2004

Birth of Sanofi-Aventis, the world's 3rd largest pharmaceutical company, ranking number 1 in Europe

August 20, 2004

Broad success of Sanofi-Synthélabo’s offer for Aventis

August 12, 2004

Sanofi-Synthélabo’s offer for Aventis. Provisional results of the offers

August 9, 2004

Sanofi-Synthélabo’s offer for Aventis. Tender period has expired

July 31, 2004

FTC Clears Sanofi-Synthélabo’s offer for Aventis shares

July 29, 2004

Very strong sales growth in the first half of 2004: consolidated sales: 4,460 million euros, up 18.9% on a comparable basis, up 14.3% on a reported basis, developed sales: up 25.5% on a comparable basis

July 21, 2004

Teva Pharmaceuticals’ ANDA does not challenge the product patent for Avapro® (irbesartan)

July 20, 2004

The U.S. Federal Trade Commission’s Bureau of Competition and Economics has completed its review of Sanofi-Synthélabo's proposed acquisition of Aventis

July 15, 2004

Sanofi-Synthelabo and Pfizer conclude an agreement on the divestment of Campto® (irinotecan) conditional upon completion of Sanofi-Synthelabo's offer for Aventis

June 25, 2004

Annual general meeting

June 24, 2004

Sanofi-Synthelabo’s offer for Aventis : expiration date of offers

June 23, 2004

Closing date of Sanofi-Synthelabo's offer on Aventis postponed to July 30, 2004

June 22, 2004

Draft structure of Sanofi-Aventis Management Committee

June 21, 2004

Sanofi-Synthelabo's offer for Aventis : Adjustment of offer terms on approval of Aventis dividend

June 14, 2004

New indications for Arixtra® in the United States: the treatment of acute deep venous thrombosis and acute pulmonary embolism

June 4, 2004

ELOXATIN™ study in New England Journal Of Medicine demonstrates significant benefit over standard therapy in early stage colon cancer

June 3, 2004

Sanofi-Synthelabo's offer for Aventis. Expiration date of offers

June 1, 2004

Sanofi-Synthelabo's offer for Aventis : U.S. offer extended to Wednesday, June 30, 2004

May 26, 2004

General Meeting of Sanofi-Synthelabo Shareholders: Sanofi-Synthelabo’s Offer for Aventis

May 26, 2004

Sanofi-Synthelabo’s Shareholders Meeting and offer for Aventis

May 14, 2004

Sanofi-Synthélabo’s Offer for Aventis: request for Additional Information from the Federal Trade Commission

May 5, 2004

Postponement of Sanofi-Synthélabo General Meeting of May 24, 2004

May 4, 2004

Approval by the European Commission of the planned acquisition of Aventis by Sanofi-Synthelabo

April 27, 2004

Agreement between Sanofi-Synthelabo and Aventis to create Sanofi-Aventis

April 26, 2004

1st quarter 2004 sales :Sustained and very strong sales growth

April 22, 2004

Press release dated April 15, 2004

April 15, 2004

Sanofi-Synthelabo to sell to GlaxoSmithKline Arixtra®, Fraxiparine® and Notre Dame de Bondeville plant

April 13, 2004

Sanofi-Synthélabo Commences U.S. Offer for Aventis

April 13, 2004

Sanofi-Synthélabo's Offer for Aventis

April 5, 2004

Alfuzosin 10 mg OD (Xatral® OD) shows beneficial effect in patients with acute urinary retention

March 25, 2004

Financing of the offer on AVENTIS

March 19, 2004

Publication of financial statements 2003

March 12, 2004

Two pivotal studies indicate ACOMPLIA™ (rimonabant) offers a novel approach to cardiovascular risk management in overweight/obese people and smokers

March 9, 2004

Outstanding 2003 performance : sales growth, 15.6% on a comparable basis, 2003 EPS growth, 21.5%, very positive R&D results

February 16, 2004

Sanofi-Synthelabo to acquire all of Taisho's 49% interest in the joint venture company Sanofi-Synthelabo-Taisho Pharmaceutical Co.

February 4, 2004

Sanofi-Synthelabo announces offer for Aventis's shares

January 26, 2004

Continued strong consolidated sales growth in 2003: 15.6 % on a comparable basis 8.1% on a reported basis

January 22, 2004

ELOXATIN™ submitted in the United States and in Europe for the adjuvant treatment of patients with colon cancer

January 19, 2004

Press release dated January 16, 2004

January 16, 2004

Eloxatin™ (oxaliplatin for injection) approved in the United States for the 1st line treatment of metastatic colorectal cancer

January 12, 2004

Sanofi-Synthelabo to acquire all interests in Arixtra®, idraparinux and other oligosaccharides from Organon

January 7, 2004

ELOXATIN® is becoming a cornerstone therapy for the treatment of metastatic colorectal cancer in Europe

January 7, 2004