Cardiovascular diseases

Formation of a blood clot

Atherosclerosis is an ageing process in arteries accompanied by an accumulation of fatty deposits and calcification. Tissues become fibrous, leading to thickening and hardening of the artery wall.

Formation of a blood clot (atherothrombosis), in an atherosclerotic blood vessel is the origin of most cardiovascular disorders: hypertension, stroke, congestive heart failure…

Foremost cause of mortality worldwide

Cardiovascular diseases are the foremost cause of mortality worldwide. They are the cause of over 17 million deaths every year, i.e. 30% of global mortality.

Sanofi-aventis approaches

Sanofi-aventis is actively developing compounds for the prevention of events connected to atherothrombosis:

• ion channel and ion transport inhibitors,
• angiotensin converting enzyme inhibitors / neutral endopeptidase,
• chemical mediator receptor antagonists,
• enzyme activators (guanylate cyclase)…

Targeted disorders

• Arterial hypertension
• Atrial fibrillation
• Peripheral arterial disease
• Heart failure
• Atherosclerosis/Restenosis
• Angina